Rcmd form of mds9/20/2023 ![]() Shanghai Jiao Tong University School of Medicine, China ![]() (2013) Alteration in Endoglin-Related Angiogenesis in Refractory Cytopenia with Multilineage Dysplasia. The differences in angiogenesis observed in RCMD patients could be related to ENG abnormalities.Ĭitation: del Rey M, Pericacho M, Velasco S, Lumbreras E, López-Novoa JM, Hernández-Rivas JM, et al. Therefore, the present study suggests that the patterns of angiogenesis are different between the MDS subtypes. Moreover, higher soluble ENG and soluble FLT-1 levels in BM microenvironment were observed in RCMD cases, which distinguished them from other individuals. In addition, the BM mononuclear cells from RCMD patients displayed over-expression of VEGF, HIF and FN1 while they showed reduced expression of ENG in contrast to the normal ENG expression of the remaining low-risk MDS and the high expression of ENG in high-risk MDS subtype. The morphology of the capillary-like structures originated by two endothelial cells lines in the BM environment of patients with refractory cytopenia with multilineage dysplasia (RCMD) was different from those of the remaining MDS. Ninety-seven MDS patients and forty-two normal BM samples were studied. In order to gain insight in MDS angiogenesis a combined analysis in bone marrow (BM) of gene expression levels, angiogenesis-related soluble factors and functional angiogenesis-related studies was carried out. ![]() The functional mechanisms involved in angiogenesis and the potential role of endoglin (ENG), recently described as a new marker for this process, have not been explored in Myelodysplastic Syndromes (MDS).
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